University of Wisconsin–Madison

High-throughput MALDI-TOF mass spectrometry for drug discovery in the ubiquitin system

When: May 31, 2017 12:00pm CST

Matthias Trost photo
Matthias Trost

High-throughput MALDI TOF mass spectrometry has become an exciting new method for drug discovery. It allows ultra-fast, label-free screening and has with its flexibility the potential to become the tool of choice for many drug discovery efforts. Here, we present the current state of MALDI TOF mass spectrometry and demonstrate a novel screening method to assay E1-E2-E3 ubiquitin ligase activity and specificity using high-throughput MALDI-TOF mass spectrometry.

Speaker: Matthias Trost, Professor of Proteomics, Newcastle University, Newscastle-upon-Tyne, UK and Program Leader and Head of Proteomics at the MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Scotland

Matthias Trost studied chemistry in Freiburg, Germany and Manchester, UK. He has a PhD in Cellular Microbiology & Proteomics from the Helmholtz Centre for Infection Research, Braunschweig, Germany and was a postdoctoral fellow with Michel Desjardins at the University of Montreal, Canada and with Pierre Thibault, Institute for Research in Immunology and Cancer, Montreal, Canada. In 2010 he became Program Leader and Head of Proteomics at the MRC Protein Phosphorylation Unit at the University of Dundee, UK. Since 2016, he is Professor of Proteomics at Newcastle University. Matthias’s research focusses on large-scale proteome and PTM analyses to understand innate immunity in macrophages. He also has a strong interest in drug discovery for which his lab developed high-throughput MALDI TOF mass spectrometry.

This webinar is a collaboration between Bruker and Division of Pharmacy Professional Development at the University of Wisconsin-Madison’s School of Pharmacy.

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