University of Wisconsin–Madison

Advancements in MALDI-TOF Mass Spectrometry towards Ultra High Throughput Screening

When: June 7, 2017 12:00pm CST

melanie leveridge photo

Mass spectrometry (MS) offers a label free, direct detection method for screening of enzyme targets and recent developments within Matrix Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF) offer an alternative to the limitations of high throughput MS detection. In this webinar we will describe the development and validation of assays for both small molecule and peptide analytes using MALDI-TOF coupled to nanolitre liquid handling. Assay validation data will be shown, as well as correlation to lower throughput MS formats. We also describe the latest advancements in the technology and sample preparation process to further increase throughput, robustness and remove bottlenecks, and future opportunities of the platform will be discussed.

Speaker: Melanie Leveridge, Head of Screening, Profiling and Mechanistic Biology, GlaxoSmithKline, Stevenage, UK

Melanie graduated from the University of Bristol, UK with first class honors in Biology, and joined GSK in 2005. She has since held roles of increasing responsibility in high throughput screening, compound profiling and assay development, predominantly in support of respiratory, neuroscience and immune-inflammation therapy areas. Melanie has particular expertise in the application of high throughput mass spectrometry techniques for screening and compound profiling.

In her current role as Director of Screening, Profiling and Mechanistic Biology, at the GSK Medicines Research Centre in Stevenage UK, Melanie leads a department of 50 scientists who partner with therapy area units to select the best targets for small molecule drug discovery approaches. Her team develop and prosecute assays and mechanistic biology studies to understand target:molecule interactions using a range of biochemical, biophysical, cellular and phenotypic assay approaches.

This webinar is a collaboration between Bruker and Division of Pharmacy Professional Development at the University of Wisconsin-Madison’s School of Pharmacy.

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