Course Objectives
In this 5-session course, we will explore clinically significant pharmacokinetic drug-drug interactions (DDIs) observed with recently FDA approved drug therapies. The possible mechanisms (e.g., inhibition or induction of metabolizing enzymes and/or transporters, changes in drug absorption, pharmacogenetics, organ impairment) will be reviewed and potential clinical outcomes explained. Mitigation strategies to prevent or minimize the risk of DDIs will be discussed.
At the end of this course, students will be able to:
- Understand the basic scientific principles of drug metabolism and drug transport and their roles in controlling drug exposure and pharmacokinetic drug-drug interactions;
- Review the main mechanisms involved in pharmacokinetic drug-drug interactions;
- Understand the concepts of marker, victim, and perpetrator drugs and know how to extrapolate the results of a marker study to common co-medications;
- Know the categorization of clinical victim and perpetrator drugs sensitivity and potency (weak, moderate, or strong) and the impact on product labeling recommendations;
- Describe common drug interactions with recently approved drug therapies;
- Examine significant drug interactions observed during the drugs’ development and discuss likely mechanism(s) and possible clinical outcomes;
- Apply mechanistic knowledge gained to predict and prevent drug interactions;
- Identify relevant resources to develop a risk mitigation strategy.
Instructors
Cathy Yeung, PharmD, PhD, MPH, Instructor, University of Washington, School of Pharmacy, Drug Interaction Solutions, Department of Pharmaceutics, Seattle, WA
Jingjing Yu, MD, PhD, Principal Investigator and Instructor, University of Washington, School of Pharmacy, Drug Interaction Solutions, Department of Pharmaceutics, Seattle, WA
Planning Committee
Leslie Dickmann, PhD, MPH, Program Director, Division of Pharmacy Professional Development, UW-Madison School of Pharmacy, Madison, WI
Isabelle Ragueneau-Majlessi, MD, MS, Senior Advisor, University of Washington, School of Pharmacy, Drug Interaction Solutions, Department of Pharmaceutics, Seattle, WA
Policy on Disclosure
It is the policy of the University of Wisconsin–Madison Interprofessional Continuing Education Partnership (ICEP) to identify, mitigate and disclose all relevant financial relationships with ineligible companies* held by the speakers/presenters, authors, planners, and other persons who may influence content of this accredited continuing education (CE). In addition, speakers, presenters and authors must disclose any planned discussion of unlabeled/unapproved uses of drugs or devices during their presentation.
For this accredited continuing education activity, all faculty, planners, and other persons who may influence content of this activity have no relevant financial relationships with ineligible companies to disclose and will not discuss unlabeled/unapproved uses of drugs or devices during their presentations.
*Ineligible companies are those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on, patients.
CE Credit
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 Accreditation Statement
In support of improving patient care, this activity has been planned and implemented by the University of Wisconsin–Madison ICEP and University of Washington. The University of Wisconsin–Madison ICEP is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
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Credit Designation Statements
Accreditation Council for Pharmacy Education (ACPE)
The University of Wisconsin-Madison ICEP designates this enduring knowledge-based activity for 4 hours (0.4 CEUs) of CPE credit. Credit can be earned by successfully completing the assessment (70% or better score) and evaluation. There will be no partial credit awarded for partial completion.
Enduring (home study): JA0000358-9999-21-068-H04-P
Release Date: 2/02/2021 Expiration Date: 12/31/2023
Continuing Education Units (CEUs)
The University of Wisconsin–Madison ICEP, as a member of the University Professional & Continuing Education Association (UPCEA), authorizes this program for 0.4 CEUs or 4 hours.
