This course helps pharmaceutical scientists get well versed in the details of PK-PD. Two important terms in drug development are “pharmacokinetics” (PK) and “pharmacodynamics” (PD).
Pharmacokinetics (PK) describes what a body does to a drug. How does it break the drug down? Is the drug broken down too fast or too slow? Is the drug available where needed? Is the drug eliminated too soon? Does it stay around too long?
Pharmacodynamics (PD) describes what the drug does to the body. Does the drug work as intended? Are there any unwanted side effects? Is there any toxic impact?
It is important to address these questions when developing a new drug. You will learn the foundations of PK-PD through basic mathematical equations. Practical examples from actual experimental data will illustrate concepts.
Upon completion, you will develop a broad PK-PD vocabulary. You will improve your communication with PK-PD scientists and foster efficient teamwork.
This course is an elective in the Applied Drug Development Certificate. Take the course as is or to fulfill the elective requirement. Scientists interested in improving their PK-PD understanding should take this course.
Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.
UW Madison-School of Pharmacy
1116 Rennebohm Hall
777 Highland Ave
Madison, WI 53705
$1350/$1100 each two or more from same company
$675 Academic/$400 Graduate Student
Drug development is dependent upon drug behavior once it is administered. This course will provide the learner with an overview of key drug metabolism concepts including availability, half-life, volume of distribution and clearance. It will also help the learner identify ways in which formulation design can affect biopharmaceutical parameters. Upon completion of this course, the learner should be able to:
Discuss the actors which influence drug availability;
Describe the concepts of a drug’s AUC, half-life, Volume of Distribution, and Clearance; and
Identify ways in which formulation design can affect biopharmaceutical parameters.
Who Should Attend
Scientists who wish to learn more about how drugs are metabolized in the body, the effects drugs have on the body and how these factors relate to the drug development process.
Slide presentations will be downloadable one week prior to the start of the course.
Monday, May 20, 2019
Welcome Eric Buxton, Ph.D.
Clinical Associate Professor
UW-Madison School of Pharmacy
Definition of Symbols
Definition of Terms
Transporters and Enzymes
Biliary Secretion and Metabolism
First pass effect
Routes of absorption
IV Bolus Dose
Oral Single Dose
Oral Multiple Dose
Calculation of Clearance and Bioavailability
4: 30 pm
Adjourment - Evening free to explore Madison
Tuesday, May 21, 2019
Plasma Protein and Tissue Binding
Apparent Volume of Distribution
Lipophilicity vs VoD
Clearance: Its physiological interpretation and its in vitro/in vivo estimation