University of Wisconsin–Madison

Pharmacokinetics and Pharmacodynamics (PK-PD)

A flask filtered on molecule design and other lab equipment for PK-PD calculationsThis course helps pharmaceutical scientists get well versed in the details of PK-PD. Two important terms in drug development are “pharmacokinetics” (PK) and “pharmacodynamics” (PD).  

Pharmacokinetics (PK) describes what a body does to a drug. How does it break the drug down? Is the drug broken down too fast or too slow? Is the drug available where needed? Is the drug eliminated too soon? Does it stay around too long?

Pharmacodynamics (PD) describes what the drug does to the body. Does the drug work as intended? Are there any unwanted side effects? Is there any toxic impact?
It is important to address these questions when developing a new drug. You will learn the foundations of PK-PD  through basic mathematical equations. Practical examples from actual experimental data will illustrate concepts.

Upon completion, you will develop a broad PK-PD vocabulary. You will improve your communication with PK-PD scientists and foster efficient teamwork.
This course is an elective in the Applied Drug Development Certificate. Take the course as is or to fulfill the elective requirement. Scientists interested in improving their PK-PD understanding should take this course.

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.

Registration Information

Register

Refund Policy

Register by: May 20, 2019
Course date:May 20, 2019 - May 23, 2019
Location:

UW Madison-School of Pharmacy
1116 Rennebohm Hall
777 Highland Ave
Madison, WI 53705

Course fee:

$1350/$1100 each two or more from same company
$675 Academic/$400 Graduate Student

Course Objectives

Drug development is dependent upon drug behavior once it is administered.  This course will provide the learner with an overview of key drug metabolism concepts including availability, half-life, volume of distribution and clearance.  It will also help the learner identify ways in which formulation design can affect biopharmaceutical parameters. Upon completion of this course, the learner should be able to:

  1. Discuss the actors which influence drug availability;
  2. Describe the concepts of a drug’s AUC, half-life, Volume of Distribution, and Clearance; and
  3. Identify ways in which formulation design can affect biopharmaceutical parameters.

Who Should Attend

Scientists who wish to learn more about how drugs are metabolized in the body, the effects drugs have on the body and how these factors relate to the drug development process.

Course Requirements

Laptops Required

Slide presentations will be downloadable one week prior to the start of the course.

Course Outline

Monday, May 20, 2019
8:15 am Welcome
Eric Buxton, Ph.D.
Clinical Associate Professor
UW-Madison School of Pharmacy
8:30 am

Introduction

  • Definition of Symbols
  • Definition of Terms
  • ADME
  • Transporters and Enzymes
10:00 am Break
10:15 am

Biliary Secretion and Metabolism

  • Enterohepatic cycle
  • First pass effect
  • Bioavailabilty
12:00 noon Lunch
1:00 pm

Drug Absorption

  • Routes of absorption
  • Permeability
1:30 pm

Compartmental Modeling

  • IV Bolus Dose
  • IV Infusion
  • Oral Single Dose
  • Oral Multiple Dose
2:30 pm

Break

2:45 pm

Calculation of Clearance and Bioavailability

  • Bioequivalence issues
4: 30 pm

Adjourment - Evening free to explore Madison

Tuesday, May 21, 2019
8:30 am Plasma Protein and Tissue Binding
  • Binding Sites
9:15 am

Apparent Volume of Distribution

  • Lipophilicity vs VoD
10:00 am

Break

10:15 am

Clearance: Its physiological interpretation and its in vitro/in vivo estimation

  • Physiological meaning of Clearance
  • Estimation from in vitro Vm/Km values
  • Species and gender differences
11:00 am

Renal Clearance

  • Calculation
  • Components
12:00 pm Lunch
1:00 pm

Conversions between Reference Fluids

  • Plasma
  • Blood
1:30 pm

Variabilities

  • Individual Variabilities in Drug Response
  • Age
  • Gender
  • Genetic Differences
2:30 pm Break
2:45 pm

Species (Allometric) Scaling

  • Application to drugs
  • Species differences
  • Considerations
4:00 pm Distribution Kinetics
4:30 pm Adjournment - Evening free to explore Madison
Wednesday, May 22, 2019
8:30 am Metabolite Kinetics
  • Importance
  • Metabolic Pathways
  • Modeling Metabolite Kinetics
    Rate limiting steps
    Hepatic metabolism influence
    Integrated Dose Dependence
9:30 am Non-compartmental Kinetics
  • Mean Residence Time
    Implications
10:00 am Break
10:15am

CNS Transporters

  • PgP
  • Blood Brain Barrier
11:30 am Lunch
12:30 pm

Pharmacodynamics

  • Relationship with Pharmacokinetics
  • Hysteresis Curves
  • Effect Models
2:00 pm Break
2:15 pm

Protein Drug Pharmacokinetics and Pharmacodynamics

  • Definitions
  • Metabolislm
  • Lymphatic Transport
  • Nonlinearities
4:30 pm Adjournment - Evening free to explore Madison
Thursday, May 23, 2019
8:30 am

Physiological Pharmacokinetic Models

  • Advantages
  • Disadvantages
  • Examples
10:00 am Break
10:15 am

PK and PD Nonlinearities

  • Causes
  • Types
  • Examples
11:30 am Adjournment

Instructors

Ronald Burnette, PharmD, PhD
Professor
University of Wisconsin-Madison School of Pharmacy

Accommodations

Room Block:

Best Western Plus
InnTowner Madison
2424 University Ave
Madison, WI  53726
Phone: 608.233.8778
Group Rate: $122.00 per night
Group Code: PHARM19

Block release date: April 19, 2019

Program Coordinator

Eric Buxton, PhD

Division of Pharmacy Professional Development
777 Highland Avenue
Madison, WI 53705
(608) 262-2431 FAX
(608) 265-2259
eric.buxton@wisc.edu

Customized Course Request