University of Wisconsin–Madison

Pharmacokinetics and Pharmacodynamics (PK-PD)

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.

A flask filtered on molecule design and other lab equipment for PK-PD calculations

This course will teach pharmaceutical scientists the essential elements of pharmacokinetics and pharmacodynamics (PKPD).  While PK describes what a body does to a drug, PD describes what the drug does to the body, and both aspects are important concepts in drug development.  Through this course, you will learn foundational concepts of PK such as clearance, exposure, and bioavailability and how they are applied in drug development.  Basic mathematical equations will also be explained; however, the focus will be on higher level concepts and not complex math.  Fundamental PD concepts will also be described, and the inseparable relationship between PK and PD will be discussed.

Also covered in this course are topics in which fundamental PK knowledge is essential.  These include drug-drug interactions (DDI), bioequivalence, and dosing in special populations.  As PK permeates many aspects of drug development, lectures will also discuss PK in the context of preclinical and clinical research and how PK can impact drug development.  Lastly, regulatory guidelines governing PKPD studies will also be introduced. 

The 2022 PKPD short course is an online course with live and recorded components.  There are 4 live webinar sessions designed for student/faculty interaction.  Prior to the first session, and in between the remaining sessions the students will be assigned recorded lectures and reading that will provide the basis of the live discussion for that session.

Upon completion of this course, you will develop a broad PKPD vocabulary and improve your communication and interactions with PKPD scientists to foster efficient and effective teamwork.  This course is also an elective for the Drug Product Development Certificate and may be taken to fulfill the elective requirement.

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.

Registration Information

Register

Refund Policy

Course date:May 17, 2022 - May 25, 2022
Location:
Course fee:

This course will consist of four live webinars via Zoom as well as asynchronous course work. The four live webinar sessions will be May 17, 18, 24 & 25 at 10:00 AM - 2:00 PM CST.

$1400
$1150 two or more from same company
Cancellations after May 3, 2022 are non-refundable. Cancellations prior to that date are subject to a $75 administration fee. In the event that a registrant cannot attend, a substitute may be sent.

Please contact us to qualify for an academic and graduate student rate.

Course Objectives

This course will provide the learner with fundamental knowledge of PKPD concepts, vocabulary, and biology.  The high-level course objectives are:

  1. Describe basic PK concepts and their application in drug development
  2. Define fundamental PK parameters and why they are important
  3. Explain the link between PK and PD and how this can be used to understand drug action
  4. Build confidence in interacting with PKPD scientists on your drug development teams

Who Should Attend

Scientists who wish to learn more about the basic tenets of PKPD with an emphasis on the concepts, vocabulary, and biology of PK.  This course is not intended for scientists who already possess a solid understanding of PK principles and their application in drug development.

Course Outline

Course library
  • PKPD glossary
  • Assorted journal articles and book chapters
  • Recorded lecture on bioanalytical considerations for PKPD
  • Recorded lecture on the BCS and BDDCS and application to PK
  • Problem sets
To be completed prior to webinar on May 24

Complete 5 part series: Principles and Mechanisms of Pharmacokinetic Drug-Drug Interactions for Recently Approved Drugs 

  1. Basic Principles and Main Mechanisms of Pharmacokinetic Drug Interactions Speaker: Cathy Yeung, PharmD, PhD, MPH, Instructor, University of Washington (UW) Drug Interaction Solutions, Department of Pharmaceutics
  2. Drugs Recently Approved by FDA (2013-2017) - Metabolism-based Drug Interactions Instructor: Jingjing Yu, MD, PhD, Principal Investigator and Instructor, University of Washington (UW) Drug Interaction Solutions, Department of Pharmaceutics

  3. Drugs Recently Approved by FDA (2013-2017) - Metabolism-based Drug Interactions Instructor: Jingjing Yu, MD, PhD

  4. Drugs Recently Approved by the FDA (2013-2017) – Absorption-based Drug Interactions and Food-Effects Instructor: Jingjing Yu, MD, PhD

  5. Impact of Patient Factors: Pharmacogenetics, Organ Impairment, and Natural Product-Drug Interactions Instructor: Cathy Yeung, PharmD, PhD, MPH

May 17

Session 1: Opening Live Webinar - Tuesday, May 17, 2022 (approximately 4.0 hours)
10:00 AM - 2:00 PM CST

  1. Overview of basic PK concepts -  ADME basics
  2. Overview of basic PK concepts - routes of administration, compartmental vs non-compartmental analysis
  3. Fundamental PK concepts and descriptive parameters
  4. Q&A and description of problem set #1
May 18

Session 2: Live Webinar - Thursday, May 18, 2022 (approximately 4.0 hours)
10:00 AM - 2:00 PM CST

  1. Explanation of problem set #1
  2. Analysis of PK data and understanding the parameters
  3. Accumulation and single vs multiple dosing
  4. Preclinical and translational considerations
  5. Q&A and description of problem set #2
May 24

Session 3: Live Webinar - Tuesday, May 24, 2022 (approximately 4.0 hours)
10:00 AM - 2:00 PM CST

  1. Explanation of problem set #2
  2. Clinical  considerations for PKPD analysis
  3. PKPD in special populations
  4. Drug-drug interactions
  5. Q&A and description of problem set #3
May 25

Session 4: Live Webinar - Thursday, May 25, 2022 (approximately 4.0 hours)
10:00 AM - 2:00 PM CST

Special Topics in PK (4 hours)

  1. Explanation of problem set #3
  2. Small molecule vs macromolecule PK
  3. Pharmacodynamics
  4. PKPD modeling approaches
  5. Q&A and wrap-up

Instructors

Leslie Dickmann, PhD, MPH
Faculty Associate
School of Pharmacy
University of Wisconsin, Madison

Robert J. Guttendorf, RPh, PhD
Aclairo Pharmaceutical Development Group, Inc.
Adjunct Assistant Professor
School of Pharmacy
University of Wisconsin, Madison

Sin Yin (Sean) Lim, PharmD, MS
Assistant Professor (CHS)
School of Pharmacy
University of Wisconsin, Madison

Program Coordinator

Leslie Dickmann, PhD, MPH

Division of Pharmacy Professional Development
777 Highland Avenue
Madison, WI 53705
(608) 262-2431 FAX
(608) 265-8249
ljdickmann@wisc.edu