University of Wisconsin–Madison

Annual Drug Metabolism and Applied Pharmacokinetics-DMPK Conference (September Land O’ Lakes)

Found in Translation: Adaptive DMPK Strategies

Attendees at the Drug Metabolism and Applied Pharmacokinetics Conference

The Land O’Lakes Conferences are recognized worldwide as one of the premier teaching conferences for pharmaceutical scientists. The September Land O’Lakes Conference on Drug Metabolism and Applied Pharmacokinetics is a three-day conference that brings leaders from multiple disciplines in the DMPK arena together to share new advances in drug delivery, action and metabolism. Relevant regulatory updates are provided every year to ensure that the attendees are aware of the latest changes in drug development regulations.

AAPS logo

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison in partnership with AAPS (American Association of Pharmaceutical Scientists).

 

 

Registration Information

Register

Refund Policy

Course date:Sep 9, 2019 - Sep 12, 2019
Location:

Fluno Center
601 University Avenue
University of Wisconsin-Madison Campus
Madison, WI

Course fee:

$1075 Conference Registration Fee
$1375 Conference Registration Fee after August 26, 2019
$850 Academic-Government Conference Registration Fee

Conference Registration Fee includes the opening dinner and all receptions.

$175 Optional Short Course Fee

Refund Policy: All requests for refunds, less a $75 administrative fee, will be honored if received prior to August 26, 2019. No refunds will be provided after that date.

Course Objectives

Overall Goal:

The 22nd Annual DMPK Conference will discuss the current issues in selecting potential new therapeutic entities for drug development and current issues in drug metabolism, drug transport, pharmacokinetics, and pharmacodynamics.

Conference objectives:

The objectives for this conference include:

  1. To provide a forum to discuss the role of absorption, distribution, metabolism, and elimination (ADME) in the pharmacokinetics and pharmacodynamics of new product candidates, including small molecular entities, biologicals, and biotechnology-derived molecules.
  2. To facilitate insight into problems and issues encountered during the drug discovery and lead optimization processes and with the interface between drug discovery and development..
  3. To discuss current regulatory issues affecting preclinical and clinical development, within the United States and globally.
  4. To identify processes for improving the identification of successful drug candidates using ADME technologies, in-vitro/in-vivo relationships, and modeling and simulation.
  5. To discuss current ADME experimental systems and their applicability in R&D activity.
  6. To gain insight on the drug-development process from various perspectives, including industry, academia, and regulatory agencies.
  7. To discuss new technologies and processes that help describe the ADME characteristics of potential therapeutic entities and mechanisms of biotransformation.

Poster Session:

The Planning Committee for the 22nd Annual Land O’Lakes Conference on Drug Metabolism and Pharmacokinetics and Applied Drug Development, invites interested parties to submit research poster abstracts for the 2019 Conference Poster Session on Wednesday, September 18, at the Fluno Center, Madison, Wisconsin. 

All abstracts must be submitted via email to the University of Wisconsin by Monday, July 15, 2019.  Proposals will be reviewed and evaluated by a review panel of Planning Committee members.  Acknowledgement of receipt will be sent by e-mail, as well as notification of the acceptance or rejection of abstracts to primary presenters by August 5.  Please do not call the University of Wisconsin to find out the status of your abstract(s).  

To submit a poster for consideration, at least one author must be registered for the conference.  If the poster is not accepted, authors have the right to cancel their registration by the registration deadline of August 26 and will receive a full refund.  Any author present at the Conference must be registered for the entire Conference.

Accepted abstracts will be placed on the University of Wisconsin Web site by August 12, 2019.

Call for Posters 2019DMPK

September 2018 LOL poster abstracts

Course Outline

Monday, September 9, 2019
1:00 pm - 4:30 pm Optional Pre-Conference Short Course

Human PK and Dose Prediction
  • Small Molecule PK Prediction
    Speaker: Miaoran Ning, PhD, Senior Scientist, PBPK modeler, AbbVie
  • Human Dose Projection for Large Molecules
    Speaker: Colin Phipps, PhD, AbbVie
  • Using PK/PD to Predict Human Doses for Small Molecules in Oncology
    Kelly Turner, PhD, Principal Research Scientist, Eli Lilly & Co.
5:00 pm Registration for Conference
5:00 pm Opening Reception
Sponsored by: TBA
6:00 PM

Opening Dinner: David Hartman Memorial Dinner
Sponsored by: TBA

6:30 pm

Welcome
Eric C. Buxton, PhD, Conference Program Coordinator and Division Chair, Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison, Madison, WI

Dinner Speaker: TBA

Tuesday, September 10, 2019
7:30 am Continental Breakfast
  First Plenary Session: Endogenous Biomarkers
Moderator: Mike Sinz, PhD, Bristol-Myers Squibb
8:25 am Welcome and Conference Overview
2019 DMPK Conference Chair Mike Sinz, PhD
8:30 am Can Coproporphyrin be Used as Endogenous Biomarker to Predict OATP1B-Mediated Drug-Drug Interactions? An industry Perspective
Speaker: Hong Shen, PhD, Bristol-Myers Squibb
9:25 am Discussion
9:35 am Challenges Associated with the Quantitative Analysis of Large and Small Molecule Endogenous Biomarkers by LC-MS/MS
Speaker: Seth Bell, PhD, Senior Research Chemist, Charles River Labs
10:15 am Discussion
10:25 am Networking Break
10:45 am TBA
Speaker: James Gosset, PhD, DMPK Senior Principal Scientist, Pfizer Inc.
11:25 am Discussion
11:35 am TBA
Speaker: TBA
12:20 pm Discussion
12:30 pm Lunch/Networking
  Second Plenary Session: Target Mediated Drug Disposition (TMDD)
Moderator: Larry Jolivette, PhD, Senior Director, GlaxoSmithKline
1:15 pm Use of TMDD-Like Models to Explore Strategies to Optimize Dose Efficiency for Antibodies That Bind Soluble Ligands
Speaker: Ryan Hansen, PhD, Senior Research Advisor, Eli Lilly and Co
1:55 pm Discussion
2:05 pm PK/PD Modeling Based FIH Estimation: Considerations and Strategies
Speaker: Mingguang Li, PhD, Lead Staff Scientist, Pharmacokinetics, Covance
2:45 pm Discussion
2:55 pm Networking Break
3:10 pm Target-Mediated Drug Disposition in the Small Molecule Space: Considerations in Drug Discovery and Early Development
Speaker: Kari Fonseca, PhD, Senior Principal Scientist, Pfizer Inc.
3:45 pm Discussion
3:55 pm Integrating Mechanistic PBPK/PD Modeling with Machine Learning to Improve Exposure and Dose Prediction
Speaker: Robert Bondi, PhD, Investigator, GlaxoSmithKline
4:30 pm Discussion
4:40 pm Adjourn
5: 00 pm Evening Reception
Transportation to Wisconsin Brewery
Sponsors: TBA
8:00 pm Evening free to explore Madison
Wednesday, September 11, 2019
7:30 am Continental Breakfast
  Third Plenary Session: Disposition in New and Nontraditional Therapeutic Mechanisms
Moderator: TBA
8:30 am Absorption of Different Drug Modalities
Speaker: John Morrison, PhD, Senior Research Investigator, Bristol-Myers Squibb
9:20 am Discussion
9:30 am PD as Surrogate for PK in Oligos-Ionis
Speaker: Diane Ramsden, PhD, Senior Scientist, Alnylam Pharmaceuticals
10:15 am Discussion
10:25 am Networking Break
10:50 am Modifying Small Molecule Disposition by Targeting Interaction with mAB
Speaker: Brandon Turunen, PhD, Head, Synthetic Immunology, GlaxoSmithKline
11:35 am Discussion
11:45 am RIP'ing Up The "Small" Molecule Drug Discovery Book!
Speaker: Paul Scott Stevens, MSc, DMPK Director, GlaxoSmith Kline
12:20 pm Discussion
12:30 pm Lunch/Networking
  Fourth Plenary Session: Regulatory Updates in DMPK
Moderator: Jennifer Thomas, PhD, ADME/DMPK, Charles River Labs
1:30 pm Regulatory Guidance for In Vitro Drug Interactions: FDA versus EMA versus PMDA
Speaker: Andrew Parkinson, PhD, CEO, XPD Consulting
2:05 pm Discussion
2:15 pm Updates on Endogenous Biomarkers
Speaker: Maciej Zamek-Gliszczynski, PhD, Director, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline
2:50 pm Discussion
3:00 pm Networking Break
3:20 pm A Novel Approach to Conducting Primate and Dog Metabolism Studies Allowing Animals to be Group Housed-Enhancing Welfare and Science
Speaker: John Kendrick, PhD, Director, Global Metabolism & Pharmacokinetics, Covance
3:55 pm Discussion
4:05 pm Practical Applications of PBPK Modeling in Clinical Drug Development
Speaker: Mohammed Shebley, PhD, Director & Research Fellow, Clinical PKPD, AbbVie
4:40 pm Discussion
5:00 pm Adjourn
5:00 pm Graduate Research Presentations, Poster Session andS ponsor Exhibit Reception
Sponsors: TBA
8:00 pm Evening free to explore Madison
Thursday, September 12, 2019
7:30 am Continental Breakfast
  Fifth Plenary Session: Microphysiological Systems (MPS)
Moderator: Donald L. McKenzie PhD, Covance Laboratories
8:30 am Macrophysiological Systems-Cancer Treatments
Speaker: Matt Gevaert, PhD, CEO, Kiyatec
9:15 am Discussion
9:25 am Physiological Flow and Vascular Cells to a 3D Liver Culture
Speaker: Craig Simmons, PhD, Distinguished Professor of Mechanobiology, University of Toronto
10:00 am Discussion
10:10 am Networking Break
10:30 am Microphysiological Systems: How Can We Apply Them in DMPK Science:
Speaker: Edward Kelly, PhD, Associate Professor, Dept. of Pharmaceutics, University of Washington
11:05 am Discussion
11:15 am Conference Wrap up & Closing remarks
Eric Buxton, PhD, 2019 ConferenceCoordinator
Mike Sinz, PhD, 2019 Conference Chair
11:30 am Conference Adjournment

Instructors

Seth Bell, PhD, Senior Research Chemist, Charles River Labs, Cleveland, OH

Robert Bondi, PhD, Investigator, GlaxoSmithKline, Collegeville, PA

Kari Fonseca, PhD, Senior PrincipalScientist, Pfizer Inc., Cambridge, MA

Matt Gevaert, PhD, CEO, Kiyatec, Greensville, SC

James Gosset, PhD, DMPK Senior Principal Scientist, Pfizer Inc., Boston, MA

Ryan Hansen, PhD, Senior Research Advisor, Eli Lilly and Co, Salt Lake City, UT

Edward Kelly, PhD, Associate Professor, Dept. of Pharmaceutics, University of Washington, Seattle, WA

John Kendrick, PhD, Director, Global Metabolism & Pharmacokinetics, Covance, Madison, WI

Mingguang Li, PhD, Lead Staff Scientist, Pharmacokinetics, Covance, Madison, WI

Donald L. McKenzie PhD, Covance Laboratories, Madison, WI

John Morrison, PhD, Senior Research Investigator, Bristol-Myers Squibb, Princeton, NJ

Miaoran Ning, PhD, Senior Scientist, PBPK modeler, AbbVie, Lake Bluff, IL

Andrew Parkinson, PhD, CEO, XPD Consulting, Shawnee, KS

Colin Phipps, PhD, AbbVie 

Diane Ramsden, PhD, Senior Scientist, Alnylam Pharmaceuticals, Boston, MA

Hong Shen, PhD, Bristol-Myers Squibb, Wallingford, CT

Mohammed Shebley, PhD, Director & Research Fellow, Clinical PKPD, AbbVie, Chicago, IL

Craig Simmons, PhD, Distinguished Professor of Mechanobiology, University of Toronto, Toronto, ON

Paul Scott Stevens, MSc, DMPK Director, GlaxoSmith Kline, Stevenage, UK

Jennifer Thomas, PhD, ADME/DMPK, Charles River Labs, Ashland, OH

Kelly Turner, PhD, Principal Research Scientist, Eli Lilly & Co. Indianapolis, IN 

Brandon Turunen, PhD, Head, Synthetic Immunology, GlaxoSmithKline, Philadelphia, PA    

Maciej Zamek-Gliszczynski, PhD, Director, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, PA

Accommodations

Hotel accommodations are the responsibility of the registrant.

Fluno Center
(conference location)
601 University Ave
Madison, WI  53715
608.441.7148   877.773.5866
$143.00
Release date: August 11, 2019
Booking link

Hampton Inn
(2.5 blocks away)
440 West Johnson St
Madison, WI  53703
608.255.0360
$169.00
Release Date: August 8, 2019
Group Name: Drug Metabolism Conference Group Code: DRG
Booking link

DoubleTree by Hilton Madison
(2 blocks away)
 525 West Johnson St
Madison, WI  53703
608.251.5511
$189.00
Release Date: August 9, 2019
Booking link

The Lowell Center
(3 blocks away)
610 Langdon St
Madison, WI  53703
608.256.2621
$115.00
Group Code: LANDDMPK
Release Date: August 9, 2019
Booking link

Graduate Hotel
(3 blocks away)
601 Langdon Street
Madison, WI  53703
608.257.4391
Rate: $189.00
Room block held until July 29
Booking link

Program Coordinator

Eric Buxton, PhD

Division of Pharmacy Professional Development
777 Highland Avenue
Madison, WI 53705
(608) 262-2431 FAX
(608) 265-2259
eric.buxton@wisc.edu