Drug metabolism is how organisms break down drugs. Developing effective new drugs requires a thorough understanding of how the drugs will act once they are administered to the patient. This learn-at-your-own-pace online course is designed to provide scientists and regulatory professionals with a basic understanding of drug metabolism and its role in drug discovery and development.
For detailed information, please view the course outline below.
Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.
Academic and Non-profit
Please contact the course coordinator for more information.
The purpose of this online course is to provide the learner with a basic understanding of drug metabolism and its role in drug discovery and development. This self-paced course consists of approximately 5 hours of recorded lectures and materials. There are no assignments to be turned in.
Goals and Objectives
Upon completion of the program the learner will be able to:
Recognize the identity, distribution, regulation and species-related differences of major drug-metabolizing enzymes and transporters;
Evaluate the appropriate application of experimental models and protocols to drug metabolism and transport issues in vivo and in vitro during discovery;
Interpret the relative importance of various metabolic pathways;
Describe how information from the drug discovery phase is used in making preclinical decisions on preclinical drug candidates;
Utilize data from in vitro and in vivo drug metabolism and transport experiments to predict drug disposition in humans; and
Explain scientific and regulatory expectations with respect to drug metabolism and transport studies, and the impact of these studies in accelerating drug development.
Who Should Attend
Scientists, technicians and regulatory professionals who desire to learn the essentials of drug metabolism, a key aspect of the drug development process.
An Overview of Drug Metabolism
2. Elimination Routes
Phase I Enzymes
1. Cytochromes P450 Monooxygenase (CYP450) System
a) Structure and Function
b) Gene Families and Substrate Specificity
c) Mechanism of Oxygen Activation
d) Reactions Catalyzed by CYP450’s
e) Induction and Inhibition of CYP450 isoforms
f) Genetic Polymorphism of CYP450 genes
g) Clinical Relevance of CYP450 Induction/Inhibition
2. Flavin Monooxygenases
3. Other Oxidases
a) Aldehyde Oxidase/Dehydrogenase
b) Alcohol Dehydrogenase