University of Wisconsin–Madison

Cardiovascular Physiology, Pharmacology and Safety

A Practical Review

Knowledge of the cardiovascular physiology, pharmacology, and safety is a key to moving drug projects forward. A drug development scientist must also understand cardiovascular receptor pharmacology.

Image of heart Cardiovascular Physiology, Pharmacology and Safety

This course will provide pharmacological strategies for management and correction of cardiovascular diseases. You will also learn safety issues associated with the cardiovascular system. At the end of this course, you will have a cardiovascular system “toolbox” at your disposal. This will help you make smart decisions based on proven science and avoid common pitfalls.

All course modules are 100% online and webinar-based. You may attend a live webinar or listen to a recording later. Prerecorded lectures are also available on demand. Course materials include case studies based on real life scenarios.

This course is part of the Applied Drug Development Certificate. It fulfills one elective. You may take the course as is or as part of the certificate.

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.

Registration Information

Register

Refund Policy

Register by: Apr 2, 2019
Course date:Apr 3, 2019 - May 29, 2019
Location:
Course fee:

$1050
$850 each for 2 or more from same company

Course Objectives

The purpose of this course is to provide the learner with a basic review of the fundamental physiological processes of the cardiovascular system and pharmacological strategies for management or correction of cardiovascular diseases. It will also address safety issues associated with drugs affecting the cardiovascular system. Topics covered in this course include:

  • Physiological considerations associated with the cardiovascular system including autonomic nervous system, renal and respiratory systems
  • Fluid compartments and their regulation; distribution of fluid volumes
  • Electrical conduction of the heart (ion channel function and cardiac arrhythmias)
  • Cardiac muscle function
  • Cardiovascular system function - flow, blood pressure and heart rate; how blood pressure is regulated
  • Cardiovascular receptor pharmacology
  • Drug exposure to cardiac tissue and vascular system; PK/PD modeling; autoradiography
  • Cardiovascular diseases: hypertension, congestive heart failure, ischemia, pulmonary artery hypertension, pharmaceutical-induced dysfunction
  • Pharmacological considerations in the treatment of the disease states listed above
  • Cardiovascular safety consideration of the development of oncology agents, biologics, RNAi therapy, gene therapy, peptides, small molecules, vaccines, and implantation devices
  • Overview of cardiovascular consideration in the drug development process from chemist to market

Upon completion of the program the learner should be able to:

  • Describe the physiological regulation of the cardiovascular system and what makes it work;
  • Discuss cardiovascular receptor pharmacology;
  • Identify the actions of various pharmacological classes of drugs which are associated with the therapeutic management of different diseases;
  • Explain the drug development of novel compounds for treatment of heart disease;
  • Describe the safety assessment of non-cardiac novel compounds-bringing safe compounds to the market; and
  • Apply information in the course through case studies on drug development or post market reconsiderations (eg. Vioxx, Seldane, etc)

Course Outline

Week/Unit Topic Date / Hours / Timeframe Format Subtopics Activities / Assignments

Week 1

Webinar: April 3

Orientation

Overview of cardiovascular consideration in the drug development process from chemist to market.

1 hour webinar

1 hour for intros / tutorials

Webinar

Online

1.1 Welcome
1.2 How to be successful with Moodle/online
1.3 Course expectations
1.4 Webinars
1.5 Online activities
1.5.1 Discussion participation
1.5.2 Completion of case study

Webinar: Discuss subtopics

Online resources tutorials:
• Technology requirements
• Goto Webinar
• Moodle
• How to be successful online and with discussions

Week 2

Webinar: April 10

Dr. Bruse

Physiological regulation of the
cardiovascular system
Two 1-hour segments of asynchronous followed by webinar

Webinar

Online

2.0 Cardiovascular System Part 1

2.1 Overview of the anatomical and physiological regulation of the cardiovascular system
2.2 What are the parts that makes it work

2.3 Pulmonary & Systemic Circulatory System

Webinar: Discuss subtopics / Q&A

Week 3

Webinar: April 17

Dr. Bruse

Physiological considerations with the cardiovascular system

1 hour webinar

1 hour online activity

Webinar

Online

3.0 Cardiovascular System Part 2

3.1 Overview of the physiological regulation of the cardiovascular system

3.2 Autonomic Nervous System
3.3 Blood Flow and Blood Component Functions
Webinar: Discuss subtopics / Q&A

Week 4

Webinar: April 24

Dr. Bruse

Kidney and Fluid Regulation and Blood Pressure

1 hour webinar

1 hour online activity

Webinar

Online

4.0 Kidney and Fluid Regulation
4.1
Fluid compartments and their regulation
4.2 Distribution of fluid volumes
Webinar: Discuss subtopics / Q&A

Week 5

Webinar:
May 1

Dr. Bruse

Cardiovascular system function

1 hour webinar

1 hour online activity

Webinar

Online

5.0 Receptor Pharmacology

5.1 Mechanisms of Receptors

·Understand the different classes of receptors (e.g. G-protein coupled receptors, ion receptors, etc) and the lock and key or nuclear target

·Learn the different classes of receptor ligands

·Understand the differences between agonists, partial agonists, and antagonists

5.2 Receptor Families/Subtypes
5.3 Dose Response curves, Structure Activity Relationships

5.4 Novel targeting/delivery ideas: nanoparticles, phage, lipids, etc

Webinar: Discuss subtopics / Q&A

Week 6

Webinar:
May 8

Dr. Bruse

Cardiovascular diseases

1 hour webinar

1 hour online activity

Webinar

Online

6.0 Cardiovascular Diseases
6.1
Hypertension
6.2 Congestive heart failure
6.3 Ischemia
6.4 Pulmonary artery hypertension
6.5 Pharmaceutical-induced dysfunction

Webinar: Discuss subtopics / Q&A

Week 7

Webinar:
May 15

Dr. Vargas

Biologics and Small Molecule Drug Development

1 hour webinar

1 hour online activity

Webinar

Online

7.0 Biologics vs Small Molecule Drug Development.

7.1 Differences for cardiovascular safety consideration of the development of small molecules, vaccines, and implantation devices
7.2 Cardiovascular safety consideration of the development of oncology agents (especially kinase inhibitors), biologics, and peptides
7.3 Future cardiovascular safety consideration of the development of DNA/RNAi therapy

Webinar: Discuss subtopics / Q&A

Week 8

Webinar:
May 22

Dr. Kaiser

PK/PD Modeling and Biomarkers

1 hour webinar

1 hour online activity

Webinar

Online

8.0 CV Study Design and PK/PD

8.1 CV Biomarkers

8.2 PK and PD associations

8.3 Regulatory Guidance

8.4 Available technologies

8.5 Applications

Webinar: Discuss subtopics / Q&A

Week 9

Webinar:
May 29

Dr. Bruse
Dr. Vargas

Case Study Discussion and course wrap up 1.5 hours Webinar Case study debate  

 

Instructors

Kristy D. Bruse, PhD, DSP (Diplomate in Safety Pharmacology)
Integrated Physiology and Pharmacology Consulting, LLC

Robert Kaiser, PhD, DABT
Principal Research Scientist at Minnesota Children's Hospital
Children's Hospitals and Clinics of Minnesota

Hugo M. Vargas, PhD, DSP
Scientific Director
Integrated Discovery & Safety Pharmacology
Amgen, Inc

Program Coordinator

Eric Buxton, PhD

Division of Pharmacy Professional Development
777 Highland Avenue
Madison, WI 53705
(608) 262-2431 FAX
(608) 265-2259
eric.buxton@wisc.edu

Customized Course Request