Enhance your expertise in pharmaceutical development with our Fundamentals of Solid Dosage Form Development course, offered by the University of Wisconsin–Madison’s Division of Pharmacy Professional Development.
Course Overview:
Solid dosage forms, such as tablets and capsules, are the most prevalent drug delivery systems in the pharmaceutical industry. This comprehensive course provides an in-depth exploration of the entire development process, from pre-clinical excipient selection to commercial manufacturing. Participants will gain a thorough understanding of the critical aspects of solid dosage form design and development.
Key Topics Covered:
- Patient-Centric Drug Product Design: Strategies to develop formulations that enhance patient compliance and therapeutic outcomes.
- Quality Target Product Profile (QTPP): Establishing a clear framework for desired product characteristics.
- Physicochemical Properties of Drug Molecules: Understanding how these properties influence formulation and performance.
- Biopharmaceutics and Gastrointestinal Physiology: Insights into how drug absorption and metabolism affect dosage form design.
- Solid-State Properties: Exploration of salts, co-crystals, polymorphs, and hydrates, and their impact on stability and efficacy.
- Challenges with Low/High Doses & Low Solubility: Approaches to overcome formulation hurdles.
- Amorphous Solid Dispersions: Techniques to enhance solubility and bioavailability.
- Controlled Release Technologies: Development of formulations for sustained drug release.
- Excipient Selection: Criteria for choosing appropriate excipients for immediate and controlled release forms.
- Manufacturing Processes: Detailed coverage of blending, granulation, tableting, film coating, and encapsulation.
- Continuous vs. Batch Manufacturing: Comparative analysis of manufacturing methodologies.
This course is part of the Drug Product Development Certificate. It fulfills one elective. Take the course ‘as-is’ or as part of the certificate.
Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin-Madison.