Course Info

Industry Live Course

17th Annual Land O’Lakes Annual Conference on Drug Metabolism/Applied Pharmacokinetics

Challenges in Developing Protein Therapeutics,
Using Biomarkers, and Evaluating Drug Transporters

September Land O'Lakes Conference
September 8-11, 2014
Fluno Center, University of Wisconsin
Madison, WI

Developed & Conducted by the Division of Pharmacy Professional Development, School of Pharmacy, University of Wisconsin- Madison (formerly known as Extension Services in Pharmacy)



Register online:

Register Now button

$1550 ($1800 after 8/18/2014)

Other ways to register:

1. Register by phone at 608.262.3132 or toll free: 877.947.4255.

2. Download the registration form, complete and mail to:

Land O'Lakes DMPK Conference
Division of Pharmacy Professional Development
777 Highland Ave.
Madison, WI 53705

Or fax your registration form to us with your credit card number: 608.262.2431

Goals and Objectives

Opening reception

The purpose of this three-day conference is to provide an educational forum to discuss the current issues in selecting potential new therapeutic entities for drug development and current issues in drug metabolism, drug transport, pharmacokinetics, and pharmacodynamics. General goals associated with this conference include::

  1. To provide a better understanding of the role of absorption, distribution, metabolism, and elimination (ADME) in the pharmacokinetics and pharmacodynamics of new product candidates, including small molecular entities, biologicals, and biotechnology-derived molecules.
  2. To gain insight into problems and issues encountered during the drug discovery and lead optimization processes and with the interface between drug discovery and development..
  3. To discuss current regulatory issues affecting preclinical and clinical development, within the United States and globally.
  4. To identify processes for improving the identification of successful drug candidates using ADME technologies, in-vitro/in-vivo relationships, and modeling and simulation.
  5. To discuss current ADME experimental systems and their applicability in R&D activity.
  6. To gain insight on the drug-development process from various perspectives, including industry, academia, and regulatory agencies.
  7. To discuss new technologies and processes that help describe the ADME characteristics of potential therapeutic entities and mechanisms of biotransformation.

View 2013 conference evaluation results.

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General Information

Location and Travel

Fluno Center

The conference has moved to the University of Wisconsin and will be presented at Fluno Center in Madison, Wisconsin (http://fluno.com). The Fluno Center is located on the UW campus and within a short walk of the State Capital, shops on the State Street pedestrian mall and lakes Monona and Mendota. The conference atmosphere offers an informal setting for interaction and networking with industrial peers.

The new venue offers many advantages:

  • Choice of hotel accommodations
  • Conference facilities on the University of Wisconsin-Madison campus
  • Easy and quick access to the Madison airport; shorter drives from Chicago and Milwaukee
  • New condensed format resulting in one day less away from work!! Same number of educational contact hours.
  • Evenings free to explore Madison's restaurants and attractions
  • All the above while retaining the quality of learning, hours for learning, and a continued relaxed environment to maximize learning

For those registrants flying into Madison (MSN), the Fluno Center is 10-15 minutes from the airport. For those driving, the location is only 15-20 minutes from the intersection of Interstates 90 and 94.

Lodging & Meals

Hotel accommodations are the responsibility of the registrant. Extension Services in Pharmacy has reserved a block of guest rooms at the Fluno Center, at the DoubleTree (1 ½ blocks away) and the Hampton Inn (2 1/2 blocks away). These are available on a first come basis. View information about guest rooms at these facilities and a list of additional hotels within walking distance.

New this year: The registration fee will include continental breakfasts, buffet lunches and break service will offer options including coffee, tea and soda, as well as rolls and sweets. Sponsored social events in the late afternoons will offer appetizers and drinks.



Madison Area Information:

Things to do, attractions, restaurants: http://www.visitmadison.com
Interactive Visitor Guide: http://www.nxtbook.com/nxtbooks/greatermadison/guide_2012fallwinter/

Registration & Fees

Early Registration $1550
Registration after 8/18/2014 +$250
REGISTRATION $1800
Special rate for Academic and government employes
(prior to 8/18/2014)
$1050

Fee includes: 1) education: instruction; handout materials (electronically as pdf files); and documentation of completion; and 2) most food/beverage reauitements: daily continental breakfast, mid-am/pm breaks, lunches and all events listed in the program. Because the handout material will be provide electronically, registrants are encouraged to bring a laptop for the conference.

Enrollment Deadline / Limits

A check in the total amount payable to UNIVERSITY OF WISCONSIN should accompany your application to ensure that space will be held for you. Credit card payment is also acceptable. Total payment will be returned /refunded if space is not available.

In the event your registration is confirmed and at a later date you are unable to personally attend, a refund (less a $50 administrative fee) will be provided prior to August 18; after August 18, no refunds will be made. You may fax your registration (608) 262-2431 with payment to follow no later than August 18. After August 18, space will not be held without receipt of payment.

Laptops Required

Conference materials will no longer be presented in the traditional large blue binders. Instead all presentations will be provided as PDF files on memory sticks distributed at the beginning of the conference.

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Optional Short Course for Monday afternoon, September 8, 2014

Scientists arriving early may wish to take advantage of this optional short course opportunity to evaluate the relationship of bioanalysis to other departments working together for the development of new pharmaceuticals. Monday, September 8, 2014; 1:30-5:30 PM in the Fluno Center, Madison, WI

Evaluation of Drug Transporters in Drug Discovery and Development


Goals and Objectives:
The purpose of this course is to provide the learner with practical information and a more in-depth understanding of drug transporters. There will be an emphasis on transporters relevant to drug discovery and development, including those of interest to the regulatory agencies. At the end of the session, participants will be updated on in silico, in vitro and in vivo tools used to understand the transporter – mediated interactions of compounds. The course will conclude with a panel discussion that will help put everything together and allow for additional discussions. Upon completion of the short course, participants should be able to:

1. List the tools commonly used to evaluate drug transporters;
2. Discuss the role of transporter screening in drug discovery;
3. Identify a range of transporter evaluations that can be used for modeling in drug development; and
4. Better understand clinical data on P-gp liability

This short course has been developed and organized by Jasminder Sahi, Head of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, China.

Who should attend:
Scientists and project leaders/managers who are involved in drug discovery or development and need to understand the distribution and potential transporter mediated drug interactions of drug candidates and want a greater understanding of models that can be used to characterize these.

More information and to register

Go to: http://ce.pharmacy.wisc.edu/2014SeptLOLShortCourseInfo

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Social Activities

In addition to the educational benefits of this program, the conference is designed to provide registrants with a relaxing environment to meet and share ideas with colleagues with similar interests and network for future collaborative effort. There will be ample networking opportunities during the opening reception, round table discussions and the poster session. Evenings are free to explore Madison and the University of Wisconsin Campus.

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2014 Conference Sponsors

Special thanks for unrestricted educational grants and other support for this conference from:



Future Science Group
London, United Kingdom

 

QPS Hepatic Biosciences DMPK
Research Triangle Park, NC

SOLVO Biotechnology
Budapest, Hungary

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Contents for 2014


Monday, September 8, 2014

12:00 pm

Registration (12:00 – 6:00 PM)

1:30 pm

Optional Short Course – separate registration required

5:00 pm

Registration for Conference

6:00 pm

Opening Reception

Sponsors:

Sigma Life Science
St. Louis, MO

Seventh Wave Laboratories LLC
Chesterfield MO 63005

7:00 pm

Dinner and welcomes

James E. De Muth, Ph.D., Conference Director
Professor, School of Pharmacy
University of Wisconsin, Madison, WI

Medicinal Plants: Contemporary Use in Complementary and Alternative Medicine

Robert L. Chapman, Ph.D.
Associate Professor of Pharmaceutical Sciences
Midwestern University, Downers Grove, IL

Tuesday, September 9, 2014

First Plenary Session: Developing Biologic (Protein) Therapeutics
Moderator:

Michael W. Sinz, Ph.D., Conference Chair
Research Fellow, Pharmacokinetics and Drug Metabolism
Bristol-Myers Squibb, Wallingford, CT

8:30 am

Welcome and Conference Introduction

Michael W. Sinz, Ph.D.

8:40 am

Introduction to Biological Therapeutics

Larry C. Wienkers, Ph.D.
Pharmacokinetics and Drug Metabolism
Amgen, Seattle, WA

9:30 am

Target Mediated Drug Disposition

Kenneth Kulmatycki, Ph.D.
Senior Investigator II, Clinical PK/PD, DMPK
Novartis, Cambridge, MA

10:20 pm

Break

10:50 am

Analytical Techniques for Biologics

Xiaodong Frank Liu, PhD
Senior Research Scientist, Department of Translational Medicine
QPS, LLC, Newark, DE

11:40 am

Drug-drug Interactions with Biologics

Leslie J. Dickmann, Ph.D.
Scientist/PKPD, Therapeutic Area Lead for Ohthalmology
Genentech, South San Francisco, CA

12:30 pm

Lunch

1:30 pm

Afternoon Session: Implications of Polymorphic Expressed Enzymes and Transporters

Moderator:

Larry J. Jolivette, Ph.D.
Director of DMPK, Heart Failure Discovery Performance Unit
GlaxoSmithKline, Upper Merion, PA

1:30 pm

European Issues with Primate Research

John S Kendrick, Ph.D.
Associate Director, Department of Metabolism
Covance Laboratories Limited, Harrogate, North Yorkshire, United Kingdom

2:20 pm

Data Transparency Initiative

Reid Groseclose, Ph.D.
Investigator, Biotransformation and Drug Disposition
GlaxoSMithKline, Research Triangle Park, NC

3:10 pm

Break

3:30 pm

Round Table Discussions

Typical Gaps in Due Diligebce Packages While In-licensing
Donald L. McKenzie, Ph.D.
Executive Director, Drug Metabolism
Covance Laboratories, Madison, WI

Preclinical Techniques for Evaluating Victim DDI Risks
Steven Swanson, Ph.D.
Senior Research Advisor, Drug Disposition
Eli Lilly and Company, Indianapolis, IN

PK/PD Modeling During the Nonclinical to Clinical Transition
Gordon Loewen, Ph.D.
Senior Director, Drug Development
EnVivo Pharmaceuticals, Watertown, MA

Others to be developed

5:00 pm

Continuation of Round Tables, Reception and Tour of the Wisconsin Brewery (transportation provided)

Sponsors:

Triangle Research Labs
Research Triangle Park, NC

 

7:00 pm

Evening free to explore Madison

Wednesday, September 10, 2014

Second Plenary Session: Drug-drug Interactions

Moderator:
David A. Hartman, Ph.D.
Senior Director, Clinical Pharmacology, Pharmacokinetics and Nonclinical Development
Nuventra, Research Triangle Park, NC

8:30 am

Role of Metabolites in Drug-drug Interactions

Nina Isoherranen, Ph.D.
Associate Professor, Department of Pharmaceutics
School of Pharmacy, University of Washington, Seattle, WA

9:20 am

Genetics of Drug-drug Interactions

Gemma Dickinson, Ph.D.
Senior Research Scientist, BioMedicines
Eli Lilly and Company, Indianapolis, IN

10:10 am

Break

10:40 am

Enzyme Induction: New Insights and the Effects of Biologics

Edward L. LeCluyse, Ph.D.
Senior Research Investigator, Institute for Chemical Safety Sciences
The Hamner Institutes for Health Sciences, Research Triangle Park, NC

11:30 am

Endogenous Biomarkers to Evaluate Drug-drug Interactions

Sree Kasichayanula, Ph.D.
Principal Scientist, Quantitative Pharmacology
Amgen Inc., Thousand Oaks, CA

12:30 pm Lunch

1:30 pm

Afternoon Session: Evaluating Therapeutic Biomarkers

Moderator:
Gordon Loewen, Ph.D.
Senior Director, Drug Development
FORUM Pharmaceuticals, Watertown, MA

1:30 pm

Micro-RNA as Biomarkers

Rounak Nassirpour, Ph.D.
Principal Scientist, Biomarker Laboratories, Drug Safety Research & Development
Pfizer, Inc., Andover, MA

2:20 pm

Imaging Technology with Biomarkers

Reid Groseclose, Ph.D.
Investigator, Biotransformation and Drug Disposition
GlaxoSMithKline, Research Triangle Park, NC

3:10 pm

Break

3:40 pm

Endogenous Biomarkers Related to Transporters

Peter Ward, Ph.D.
Principal Scientist, Preclinical Development Leader (DMPK)
Janssen Research and Development, San Diego, CA

5:00 pm

Poster Session with Wine and Cheese Reception

Sponsors:

Optivia Biotechnology, Inc.
Menlo Park, CA

Covance Laboratories                                                
Madison, WI

 

7:00 pm

Evening free to explore Madison

Thursday, September 11, 2014

Third Plenary Session: Advances in Drug Transporters

Moderator:
Dan Bow, Ph.D.
Senior Scientist II, Global Pharmaceutical R&D
AbbVie Inc., North Chicago, IL

8:30 am

Clinical Relevance and Impact of Drug Transporters

Mitchell E. Taub, Ph.D.
Senior Research Fellow, Drug Metabolism and Pharmacokinetics
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT

9:20 am

Understanding Intracellular Drug Concentrations

Nathan Pfeifer, Pharm.D., Ph.D.
Senior Clinical Pharmacokineticist II, Clinical Pharmacology and Pharmacometrics
AbbVie Inc., North Chicago, IL

10:10 am

Break

9:30 am

Understanding the Contribution of Transporters to Drug Disposition

Wenqing Gao, Ph.D.
Principal Research Scientist, Translational PK/PD
AbbVie Inc., North Chicago, IL

11:00 am

PKPD Modeling with Renal Transporters

Grant Generaux
Investigator, DMPK-Mechanism and Extrapolation Technologies
GlaxoSmithKline, Research Triangle Park, NC

12:00 pm

Conference Adjournment

Distribution of Traditional Wisconsin Cheese Boxes

Sponsor:

BioreclamationIVT
Baltimore, MD

 

 


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2014 Conference Planning Committee

Michael Sinz, Ph.D., Conference Chair, Bristol-Myers Squibb, Wallingford, CT
James E. De Muth, Ph.D., Conference Director, University of Wisconsin, Madison, WI
Daniel Bow, Ph.D., AbbVie Inc., North Chicago, IL
James L. Ferrero, Ph.D., Biogen Idec, Cambridge, MA
Robert J. Guttendorf, Ph.D., Aclairo Pharmaceutical Development Group, Gaithersburg, MD
David A. Hartman, Ph.D., Kinetigen, Inc., Research Triangle Park, NC
Suhasini Iyer, Ph.D., Genentech, Inc., South San Francisco, CA
Larry J. Jolivette, Ph.D., GlaxoSmithKline, Upper Merion, PA
Gordon R. Loewen, Ph.D., EnVivo Pharmaceuticals, Cambridge, MA
Donald L. McKenzie, Ph.D., Covance Laboratories, Madison, WI
Mark N. Milton, Ph.D., Novartis Biologics, Cambridge, MA
Jasminder Sahi, Ph.D., GlaxoSmithKline, Shanghai, China
Paul Savina, Research Triangle Park, NC
Arzu Selen, Ph.D., Center for Drug Evaluation and Research, FDA, Rockville, MD
Steven Swanson, Ph.D., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
Larry M. Tremaine, Ph.D., Pfizer, Inc., Groton, CT
Richard L. Voorman, Ph.D., Covance Laboratories, Madison, WI
Ping Zhao, Ph.D., Center for Drug Evaluation and Research, FDA, Rockville, MD

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Contact Us

If you should have questions or require more information, please contact:

James E. De Muth, Ph.D.
Course Coordinator
Division of Pharmacy Professional Development
777 Highland Avenue
Madison, WI 53705
(608) 262-2431 FAX
(608) 262-3130

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Last modified: Thursday, August 28, 2014, 11:33 AM