Solubilization and Enhanced Oral Bioavailability Formulations
Industrial Short Course
November 2, 2009
Doubletree Somerset Hotel & Executive Meeting Center
200 Atrium Drive
Somerset, NJ
Short Courses for the Pharmaceutical Industry
Registration
Your registration options are as follows:
The registration is $950.00 and Early bird discounts ($750) are offered to individuals registering prior to October 18, 2009.
 |
Register Online. Login in using your user account. If you don't have a user account creating one is free & easy. |
 |
Download the registration form, complete & mail to: Pharmacy Short Courses |
 |
By phone at 608.262.3130 or toll-free at 877-947-4255 using a credit card for payment. |
 |
Download the registration form, complete & fax to 608.262.2431 using a credit card for payment. |
Goals & Objectives
Goals and Objectives
This University of Wisconsin-Madison professional development course covers background and practical aspects of solubilization and enhanced oral bioavailability formulation strategies. The formulations considered are those used in preclinical and clinical, particularly phase 1, programs for low solubility drugs. Preformulation background in solubilization is covered for pH adjustment, cosolvents, cyclodextrins, surfactants and oil-based lipids, with an emphasis on the main excipients, their levels and how to minimize the solubility measurement workload to achieve the desired formulation. The importance of precipitation upon aqueous dilution is considered for these formulations. Nonsolubilization approaches covered are milling, particularly nanomilling, and solid dispersions. The major physical tests to assess milled and amorphous solids are examined in the context of preformulation characterization and problem solving.
Short Course Program General Information
Who should attend
Scientists and technical managers who work in early drug development and who are responsible for preclinical and/or phase 1 clinical formulations. Attendees should include BS, MS and PhD graduates with less than 5 years of experience in the formulation discipline. Additional scientists and managers who would benefit from the course include those working in analytical, preformulation, various biological sciences (toxicologists, pharmacokineticists, pharmacologists), and other groups interested in gaining a better understanding of principles and practices of preformulation and early formulation development.
Location
Doubletree Somerset Hotel & Executive Meeting Center
200 Atrium Drive
Somerset, NJ 08873
(732) 469-2600
The day begins (8:00am) with a continental breakfast and includes lunch and break service throughout the day. All classes will begin at 8:30am and end at approximately 5:00pm.
Accommodations
Blocks of hotel rooms have been reserved at the DoubleTree Hotel at the rate of $99.00 per night. Reservations should be made directly with the hotel at (800) 222-TREE and request University of Wisconsin Short Courses block. To guarantee this special room rate, reservations must be made by October 16.
Enrollment & Fees
One-day Short Course (any of the six other programs) $ 950
Payment received prior to October 18, 2009: $ 750
Contents
1) Solubilization approaches used for poorly soluble compounds
2) Bioenhanced formulation strategies for phase 1 capsules and tablets, including particle size reduction techniques, amorphous forms, solid dispersions and liquid-filled capsules
3) Preformulation characterization and background for solubilization, milled and amorphous solids, as an integral part of formulation development
4) Excipients used in solubilization, nanomilling and solid dispersions, their functionality and common levels
Instructor
Mark Sacchetti, Ph.D.
Scientific Director, Zeeh Pharmaceutical Experiment Station
School of Pharmacy, University of Wisconsin–Madison, Madison, WI
Dr. Sacchetti has 14 years of industrial experience, mostly at GlaxoSmithKline, in applying physical chemistry to the physicochemical characterization of NCEs and excipients used in oral and parenteral dosage forms as well as in developing formulations for inhaled powders. Dr. Sacchetti currently serves as Scientific Director at the Zeeh Pharmaceutical Station at the University of Wisconsin School of Pharmacy, where he oversees scientific and technical aspects of contract and grant-based programs in drug discovery and development for clients on and off the University of Wisconsin-Madison campus. He supervises Station laboratory staff, provides technical training and serves as faculty for Station-offered short courses in drug development.
For More Information
James E. De Muth, Ph.D., Conference Director
Extension Services in Pharmacy
777 Highland Avenue
Madison, WI 53705
(608) 262-3130
FAX (608) 262-2431
Send Email
Special Offer for Academic Institutions
Extension Services in Pharmacy at the University of Wisconsin School of Pharmacy has instituted a new policy for industrial professional development programs to encourage greater participation by faculty, graduate students and post doctoral students at academic institutions. Programs will be offered at a significantly reduced price, based on space availability. For information about any specific course please contact Dr. James E. De Muth by email.
