Introduction to Drug Metabolism and Transporters
Industrial Short Course
May 19-22, 2008
Madison, WI
On Campus Short Courses for the Pharmaceutical Industry
COURSE IS FULL - Please proceed with the registration if you would like to be put on a waiting list
Registration
Your registration options are as follows:
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Register Online. Login in using your user account. If you don't have a user account creating one is free & easy. |
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Download the registration form, complete & mail to: Pharmacy Short Courses |
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By phone at 608-262-3132 or 608.262.3130 or toll-free at 877-947-4255 using a credit card for payment. |
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Download the registration form, complete & fax to 608.262.2431 using a credit card for payment. |
Goals & Objectives
The purpose of this course is to provide the learner with a basic understanding of drug metabolism and its role in drug discovery and development. It is specifically designed for individuals employed in the pharmaceutical industry and whose responsibilities have recently changed or will be changing to work in the area of drug metabolism. Upon completion, of this course, the learner should be able to:
- Recognize the identity, distribution, regulation and species-related differences of major drug metabolizing enzymes and transporters;
- Evaluate the appropriate application of experimental models and protocols to drug metabolism and transport issues in vivo and in vitro during discovery;
- Interpret the relative importance of various metabolic pathways;
- Discuss the current state of the art in using recombinant enzymes and sub-cellular fractions, along with HTS assay methods to profile compound libraries for CYP interactions;
- Describe how information from the drug discovery phase is used in making preclinical decision on preclinical drug candidates;
- Design the metabolism portion of an ADME program to support drug development;
- Utilize data from in vitro and in vivo drug metabolism and transport experiments to predict drug disposition in humans;
- Discuss the role of pharmacogenetics in drug metabolism; and
- Understand scientific and regulatory expectations with respect to drug metabolism and transport studies and the impact of these studies in accelerating drug development.
Last years course evaluation results.
Short Course Program General Information
Purpose
The primary objective in all short courses is to upgrade the knowledge of pharmaceutical personnel, who can then be of greater value to their respective firms. Students will work closely with one or more faculty members to allow for optimum dialogue and discussion. We also have modified some of the courses based on evaluations and suggestions from previous participants. As with all our programs, these are designed to be practical and applicable to participants' work environments. To allow for maximum faculty-student interaction, the enrollment will be limited and available to learners on a first-come basis.
Last year, over 90% agreed or strongly agreed that the program was a valuable learning experience and over 88% indicated that they would recommend the course to a colleague.
Location
Courses are presented on the University of Wisconsin-Madison Campus. Springtime in Madison and the beauty of the on-campus location provide a relaxing atmosphere for learning. Evenings can be used to explore the University and the city named by Money magazine as the "best place to live in America" in 1996. For more information about Madison, WI visit www.visitmadison.com
Accommodations
Housing information will be sent to individuals when they receive their registration confirmation. Several hotels are within a short walking distance from the conference facility. The approximate cost per night is $100.
Ending/Starting Times
Classes begin at 8:30am each morning and end approximately 4:30. Unless otherwise indicated in the course description, programs traditionally end at approximately 11:00 to 11:30 AM on the last day of the class. This allows participants to make reservations for return flights the same day.
Enrollment & Fees
Unless otherwise indicated, enrollment will be limited to 30 individuals per short course. The registration fee of $1,095.00 includes instructional costs, course materials, and coffee breaks, and lunches. Cancellations after May 2 are non-refundable. Cancellations prior to May 2 are subject to a $75 administration fee. In the event that an accepted applicant cannot attend, a substitute may be sent by the same company. Early bird discounts ($895) are offered to individuals registering prior to April May 2, 2008. In 2007, seven of the nine short courses filled before the early registration deadline. You are encouraged to register early to avoid not being able to be included in the program.
Contents
- Overview of the role of drug metabolism in pharmaceutical discovery and development
- Overview of transporters
- Review of the major cytochrome P450 and non-P450 drug-metabolizing enzymes
- High-throughput screening for metabolic stability, intrinsic clearance and drug interactions with recombinant enzymes and hepatocellular fractions
- Determination of the information required for the selection of appropriate experimental model(s)
- Design of appropriate and effective experimental protocols
- The use of information from the drug discovery phase for planning pre-clinical studies
- Design of an ADME program to support drug development
- In vitro and in vivo models in drug development
- Species and gender comparisons for drug metabolism
- Pharmacogenomics and its role in drug metabolism;
- Drug-drug interaction studies
- FDA guidances related to drug metabolism
Instructors
Richard J. Bertz, Ph.D.
Director, Clinical Discovery
Bristol-Myers Squibb
Princeton, NJ
Peter L. Bullock, Ph.D.
Senior Director, Preclinical Development
Panacos Pharmaceuticals
Gaithersburg, MD
Kathleen M. Hillgren, Ph.D.
Principal Research Scientist, Drug Disposition
Lilly Research Laboratories
Indianapolis, IN
Jill M. Kolesar, Pharm.D.
Associate Professor of Pharmacy
University of Wisconsin
Madison, WI
Richard E. Ridgewell, PhD
Associate Director, Drug Metabolism
Covance Laboratories Inc.
Madison, WI
Craig Struble, PhD
Associate Director, Drug Metabolism
Covance Laboratories Inc.
Madison, WI
Olga Trubetskoy, Ph.D.
Madison, WI
Steven Wrighton, Ph.D.
Senior Research Fellow, Drug Disposition
Lilly Research Laboratories
Indianapolis, IN
Continuing Education Credit
Extension Services in Pharmacy (ESP) at the University of Wisconsin-Madison School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmaceutical education. Participants will be required to complete a program evaluation and certificates will be mailed to pharmacists within one month of the program. This program is accredited for 21 hours or 2.1 continuing education units (CEUs).
073-000-08-007-L04-P
For More Information
James E. De Muth, Ph.D., Conference Director
Extension Services in Pharmacy
777 Highland Avenue
Madison, WI 53705
(608) 262-3130
FAX (608) 262-2431
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